Hydrochloric Acid → 3-(7-Methoxy-2-oxoquinoxalin-1(2H)-yl)propanal

Participants

Reaction Steps

1-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one (300 mg, 1.08 mmol) was dissolved in tetrahydrofuran (3 ml). 1N Hydrochloric acid (3 ml) was added to this solution and the mixture was stirred at room temperature for 3.5 hours. The reaction solution was diluted with dichloromethane and stirred, and the organic layer was then separated. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and then the solvent was removed under reduced pressure to yield 236 mg (94%) of the title compound in the form of a light brown solid.

Provenance & Evidence