Hydrochloric Acid → HCID 86724971, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-{(4S)-4-[(methoxymethyl)methyl]-2-oxopyrrolidin-1-yl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (2.21 g, 7.20 mmol) in methanol (25 ml)/tetrahydrofuran (25 ml) was added 4N Hydrochloric acid (2.5 ml) at room temperature and the mixture was heated to 60° C. and stirred with heating for 16 hours. The reaction solution was poured into a saturated sodium hydrogen carbonate aqueous solution and extracted with a mixed solvent of chloroform/methanol (9:1) (3×). The organic layer was dried over anhydrous sodium sulfate, the drying agent was removed by filtration and the filtrate was concentrated under reduced pressure. 1.76 g (93%) of a crude product of the title compound was obtained in the form of a light yellow solid.

Provenance & Evidence