HCID 86724986, compound → HCID 86724985, compound

Participants

Reaction Steps

To a solution of 6-[(4R)-4-(azidomethyl)-2-oxopyrrolidin-1-yl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (230 mg, 0.877 mmol) in methanol-tetrahydrofuran (5 ml-2.5 ml) was added 10% palladium on carbon catalyst (about 50% aqueous, 130 mg) at room temperature and the mixture was stirred at the same temperature for 2 hours under a hydrogen atmosphere. The catalyst was removed by filtration and washed with methanol, and the filtrate was concentrated under reduced pressure. The obtained residue was dissolved in dichloromethane and dried over anhydrous sodium sulfate. After removing the drying agent by filtration, the filtrate was concentrated under reduced pressure so as to yield 188 mg (90%) of the title compound in the form of a colorless solid.

Provenance & Evidence