反应详情

A mixture of 4-methoxy-2-nitroaniline (1.68 g, 10.0 mmol), ethyl glyoxylate/toluene solution (50 wt %, 1.98 ml, 10.0 mmol) and toluene (20 ml) was heated under reflux under a nitrogen gas atmosphere for 17 hours while removing water using a Dean-Stark apparatus. The solvent was removed under reduced pressure to yield [(4-methoxy-2-nitrophenyl)imino]ethyl acetate crude product.

1. temperaturewas heated
2. temperatureunder reflux under a nitrogen gas atmosphere for 17 hours
3. customwhile removing water using a Dean-Stark apparatus
4. customThe solvent was removed under reduced pressure