反应详情

In dichloromethane (10 ml) was dissolved 1-(3,3-dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one (201 mg, 0.717 mmol) under a nitrogen gas atmosphere, manganese dioxide (733 mg, 7.17 mmol) was added thereto at room temperature and the mixture was stirred at the same temperature for 17 hours. The insoluble material was removed by filtration using celite, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane/ethyl acetate) to yield 143 mg (72%) of the title compound in the form of a yellowish solid.

1. customThe insoluble material was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (n-hexane/ethyl acetate)