Ammonium Chloride → HCID 67609803, compound

Participants

Reaction Steps

Compound 4 (19 mg, 0.048 mmol) obtained in Example 4 was suspended in methanol (1.0 mL), and cerium chloride heptahydrate (36 mg, 0.096 mmol) and sodium borohydride (0.9 mg, 0.024 mmol) were added thereof at 0° C., followed by stirring at room temperature for 10 minutes. A saturated aqueous ammonium chloride solution was added to the reaction mixture, followed by extraction with ethyl acetate twice. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to yield a residue. The residue was purified by preparative thin layer chromatography to obtain the title compound (17 mg, 91%).

Provenance & Evidence