Methyl morpholine oxide → HCID 88314422, compound

Participants

Reaction Steps

To a dichloromethane solution (2 mL) containing compound 62 (10.8 mg, 0.0234 mmol) obtained in Example 52, Molecular Sieves 4 Å (200 mg), 4-methylmorpholin-N-oxide (10 mg, 0.085 mmol) and tetrapropylammonium perruthenate (3.0 mg, 0.0085 mmol) were added, followed by stirring at room temperature for 15 minutes. The reaction mixture was filtered, and the filtrate was concentrated, followed by purification by silica gel column chromatography (20 to 50% ethyl acetate/n-hexane) to obtain the title compound (4.5 mg, 42%).

Provenance & Evidence