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2,4-Dichlorobenzylamine → 3-[(2,4-Dichlorobenzyl)amino]pyridine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichlorobenzylamine | HCID 1485 | — |
| 反応物 | 3-Fluoropyridine-4-carboxylic acid | HCID 345361 | — |
| 生成物 | 3-[(2,4-Dichlorobenzyl)amino]pyridine-4-carboxylic acid | HCID 86728205 | 42% |
反応手順
The title compound was prepared in 42% yield from 2,4-dichlorobenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.49 (br s, 1H), 8.04 (s, 1H), 7.87 (d, 1H, J=5.0 Hz), 7.66 (s, 1H), 7.59 (d, 1H, J=5.0 Hz), 7.38-7.42 (m, 2H), 4.63 (s, 2H). [M+H] calc'd for C13H10Cl2N2O2, 297, 299. Found 297, 299.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08952151B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-6ad6dded4f824aa29f726909d021363f |
| 出典メモ | uspto-grants-2015_02 |