3-(Trifluoromethyl)benzylamine → 3-{[3-(Trifluoromethyl)benzyl]amino}pyridine-4-carboxylic acid

Participants

Reaction Steps

The title compound was prepared in 39% yield from 3-trifluoromethyl-benzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.47 (br s, 1H), 8.12 (s, 1H), 7.83 (d, 1H, J=5.0 Hz), 7.74 (s, 1H), 7.57-7.69 (m, 4H), 4.67 (s, 2H). [M+H] calc'd for C14H11F3N2O2, 297. Found 297.

Provenance & Evidence