HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(7-chloro-2H-chromen-4-yl)methanamine hydrochloride → 1-(7-chloro-3,4-dihydro-2H-chromen-4-yl)methanamine, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(7-chloro-2H-chromen-4-yl)methanamine hydrochloride | HCID 90236648 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Acetic acid methanol | HCID 10129899 | — |
| Product | 1-(7-chloro-3,4-dihydro-2H-chromen-4-yl)methanamine, hydrochloride | HCID 67857184 | 92% |
Reaction Steps
Hydrogenation of 1-(7-chloro-2H-chromen-4-yl)methanamine hydrochloride (500 mg, 2.6 mmol) was carried out in the presence of Raney Nickel (300 mg) in 2:1 MeOH/HOAc under 50 psi of H2 for 16 h at 30° C. The reaction was filtered through Celite and concentrated in vacuo. Precipitation from EtOAc and filtration gave 280 mg (56%) of the title compound as a white solid. [M+H] calc'd for C10H12ClNO, 198. Found 198.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952151B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-6849ba60bb7e44c690b6c88cb1241271 |
| Source note | uspto-grants-2015_02 |