Glycine → HCID 135870678, compound

HRID 1847239Notes

Reaction equation

HRID 1847239 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:30])=[C:8]2[C:22]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)=[N:21][S:20][C:9]2=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=2)[N:11]=1)=[O:5])C.[NH2:31][CH2:32][C:33]([OH:35])=[O:34]>>[C:18]([C:15]1[CH:14]=[CH:13][C:12]([C:10]2[N:11]=[C:6]([C:4]([NH:31][CH2:32][C:33]([OH:35])=[O:34])=[O:5])[C:7]([OH:30])=[C:8]3[C:22]([C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=4)=[N:21][S:20][C:9]=23)=[CH:17][CH:16]=1)#[N:19]

Participants

3

Reactant 2

HCID 750GlycineHCID 136413574HCID 136413574, compound

Product 1

HCID 135870678HCID 135870678, compound

Procedure

The title compound was synthesized in analogy to Example 1 from 7-(4-cyano-phenyl)-3-(4-fluoro-phenyl)-4-hydroxy-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester and glycine: MS (m/z) 447.1 (M−1).

Sources & evidence

ORD record
ord-458531c04bfa41c09f42a50af556d6b2
Source dataset
uspto-grants-2015_02
Patent number
US08952160B2

Reaction notes

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