Glycine → HCID 135870680, compound

HRID 1847242Notes

Reaction equation

HRID 1847242 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:30])=[C:8]2[C:22]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[N:21][S:20][C:9]2=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[N:11]=1)=[O:5])C.[NH2:31][CH2:32][C:33]([OH:35])=[O:34]>>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([C:22]2[C:8]3[C:9](=[C:10]([C:12]4[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=4)[N:11]=[C:6]([C:4]([NH:31][CH2:32][C:33]([OH:35])=[O:34])=[O:5])[C:7]=3[OH:30])[S:20][N:21]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 750GlycineHCID 136344023HCID 136344023, compound

Product 1

HCID 135870680HCID 135870680, compound

Procedure

The title compound was synthesized in analogy to Example 1 from 3-(4-Chloro-phenyl)-4-hydroxy-7-(4-methoxy-phenyl)-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester and glycine: MS (m/z) 470.0 (M+1).

Sources & evidence

ORD record
ord-687e5a7680e645c1b8de0ff87c945d57
Source dataset
uspto-grants-2015_02
Patent number
US08952160B2

Reaction notes

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