Triethylamine → HCID 86649351, compound

Participants

Reaction Steps

To a solution of 3-(4-chloro-phenyl)-4-hydroxy-7-iodo-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester (0.47 mmol) in CH2Cl2 (2.38 mL) was added trimethylacetyl chloride (0.57 mmol) and Et3N (0.71 mmol). The reaction mixture was stirred at r.t. for 2 h before the mixture was filtered. The filtrate was concentrated in vacuo and the residue purified by flash column chromatography on silica gel. Eluting with 0-20% EtOAc/CH2Cl2, gave the title compound (225 mg) as a white solid: MS (m/z) 544.9 (M+1).

Provenance & Evidence