4-Phenoxyphenylboronic acid → HCID 136344027, compound

HRID 1847267Notes

Reaction equation

HRID 1847267 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])=[N:14][S:13][C:9]2=[C:10](Br)[N:11]=1)=[O:5])[CH3:2].[O:24]([C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])=[N:14][S:13][C:9]2=[C:10]([C:34]2[CH:35]=[CH:36][C:31]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:32][CH:33]=2)[N:11]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27343774-Phenoxyphenylboronic acidHCID 136344035HCID 136344035, compound

Product 1

HCID 136344027HCID 136344027, compound

Procedure

The title compound was synthesized in analogy Example 1 from 7-bromo-3-(2-fluoro-phenyl)-4-hydroxy-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester and 4-phenoxyphenylboronic acid: MS (m/z) 487.1 (M+1).

Sources & evidence

ORD record
ord-56005c97716e44b3938b6059142bd8c3
Source dataset
uspto-grants-2015_02
Patent number
US08952160B2

Reaction notes

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