HuagongsheHuagongshe Chemistry Print Report · For research reference only
2H-Pyran-3(4H)-one, dihydro- → 3-(5-Chloro-2-fluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2H-Pyran-3(4H)-one, dihydro- | HCID 90109 | — |
| Reactant | 5-Chloro-2-fluorobenzoyl chloride | HCID 2773604 | — |
| Reactant | tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate | HCID 59345327 | — |
| Product | 3-(5-Chloro-2-fluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole | HCID 59345329 | — |
Reaction Steps
Intermediate 16C was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one, and replacing 3,4-difluorobenzoyl chloride with 5-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=253 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741350B1 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-dbdbeb6fa9e542b3be984fed265beae6 |
| Source note | uspto-grants-2010_06 |