4-Bromo-6-cyanobenzo[d]thiazole-2-thiolate potassium salt → 4-Bromo-2-(methylthio)benzo[d]thiazole-6-carbonitrile

HRID 1848196Notes

Reaction equation

HRID 1848196 reaction equation
[K+].[Br:2][C:3]1[C:8]2[N:9]=[C:10]([S-:12])[S:11][C:7]=2[CH:6]=[C:5]([C:13]#[N:14])[CH:4]=1.[K].S[C:17]1SC2C(N=1)=NC=C(C(OCC)=O)C=2>>[Br:2][C:3]1[C:8]2[N:9]=[C:10]([S:12][CH3:17])[S:11][C:7]=2[CH:6]=[C:5]([C:13]#[N:14])[CH:4]=1

Participants

3

Reactant 2

HCID 866811654-Bromo-6-cyanobenzo[d]thiazole-2-thiolate potassium saltHCID 178469699HCID 178469699, compound

Product 1

HCID 866811644-Bromo-2-(methylthio)benzo[d]thiazole-6-carbonitrile

Procedure

4-Bromo-2-(methylthio)benzo[d]thiazole-6-carbonitrile was synthesized as a yellow solid (1.0 g, 12%) using a procedure analogous to that described in Step 2 of Example 114, substituting 4-bromo-6-cyanobenzo[d]thiazole-2-thiolate potassium salt from the previous step for ethyl 2-mercaptothiazolo[4,5-b]pyridine-6-carboxylate potassium salt used in Example 114. LCMS (ESI) m/z 284, 286 (M+H)+.

Sources & evidence

ORD record
ord-accddcf3b8c54430a76a17fbd324a587
Source dataset
uspto-grants-2015_02
Patent number
US08952058B2

Reaction notes

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