HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile → (4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile | HCID 86681168 | — |
| Reactant | 4,7-Difluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile | HCID 86681172 | — |
| Product | (4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine | HCID 86681175 | — |
Reaction Steps
(4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine was synthesized as a clear oil (646 mg, 64%) using a procedure analogous to that described in Step 3 of Example 154, substituting 4,7-difluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile from the previous step for 5-fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile used in Example 154. LCMS (ESI) m/z 247 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952058B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-49b402b7a0034b97a2561bee2e960344 |
| Source note | uspto-grants-2015_02 |