HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Oxopropoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(3,3-Diethoxypropoxy)benzamide | HCID 63630146 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-Oxopropoxy)benzamide | HCID 63040426 | 96% |
Reaction Steps
5 g of the product obtained in Step A, 100 ml of THF and 94 mL of 1N hydrochloric acid solution are added to a flask. The mixture is stirred at ambient temperature for 1 hour. The aqueous phase is extracted with dichloromethane, and then the organic phases are concentrated under reduced pressure. The product is obtained in the form of a solid in a yield of 96% and with a chemical purity of 93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952179B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-13e49621ab7a414baf528e71a2e0b753 |
| Source note | uspto-grants-2015_02 |