Lithium Hydroxide → HCID 46830634, compound

Participants

Reaction Steps

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester (0.39 g, 1.08 mmol) was suspended in 1,4-dioxan (10 mL) and aq. LiOH (68 mg, 1.6 mmol in 1.6 mL H2O) and stirred at it for 17 h. The mixture was concentrated in vacuo. The crude was suspended in H2O (3 mL) and 4N HCl (0.6 mL) was added. The aqueous phase was extracted with DCM (×3). The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. This afforded the title compound as a slightly coloured solid.

Provenance & Evidence