Dimethylformamide → HCID 46830918, compound

Participants

Reaction Steps

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (27 mg, 0.08 mmol) was dissolved in DCM (0.3 mL). Oxalyl chloride (0.008 mL, 0.09 mmol) and drop of DMF was added. Stirring for 5 min. Oxalyl chloride (0.003 mL) was added. After 20 min the suspension was concentrated and re-suspended in dioxan (0.3 mL). Aq. NH3 (25%, 0.1 mL) was added. The suspension was stirred at rt for 2 h after which it was concentrated in vacuo. The crude product was mixed with aq. Na2CO3 and the aqueous phase was extracted with DCM (×3). The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. The title compound was obtained as a slightly coloured solid.

Provenance & Evidence