Triethylamine → HCID 66707411, compound

Participants

Reaction Steps

Under an argon atmosphere C-[1-(8-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-cyclopropyl]-methylamine (0.063 g, 0.29 mmol) was dissolved in THF (1 mL) and Et3N (0.06 mL, 0.43 mmol). Cyclopentyl chloroformate (0.053 g, 036 mmol) was added. Stirring was performed at RT for 24 h. Aq. NaHCO3 and H2O were added. The aqueous phase was extracted with DCM (×3). The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography using toluene:EtOAc 2:1->1:1 as the eluent to afford [1-(8-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-cyclopropylmethyl]-carbamic acid cyclopentyl ester.

Provenance & Evidence