Potassium Carbonate → HCID 46831221, compound

Participants

Reaction Steps

In a screw cap vial pyrrolidine-1-carboxylic acid [1-(5-iodo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-cyclopropylmethyl]-amide was dissolved in DME (0.45 mL) and 1 M K2CO3 (0.14 mL) under argon. 3-cyanophenyl boronic acid (0.021 g, 0.15 mmol) and Pd(PPh3)4 (4 mg, 0.004 mmol) were added. The suspension was shaken at 80° C. for 17 h after which brine was added, and the aqueous phase was extracted with DCM (×3). The combined organic phases were dried, filtered and concentrated. The crude product was purified by flash chromatography using DCM:MeOH 97:3 as the eluent to afford the amorphous title compound.

Provenance & Evidence