Lithium Hydroxide → HCID 58074573, compound

Participants

Reaction Steps

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester (compound 188) (0.32 g, 0.88 mmol) was dissolved in 1,4-dioxan (10 mL) by heating. LiOH (0.06 g, 1.4 mmol) in H2O (2.5 mL) was added at RT. The suspension was stirred at RT overnight. The reaction mixture was concentrated in vacuo and H2O was added. The aqueous phase was washed with EtOAc and acidified with 4N HCl to pH 1. The aqueous phase was extracted with DCM (×2) and dried over MgSO4, filtered and concentrated in vacuo. This afforded the title compound as a solid.

Provenance & Evidence