反应详情

Under an argon atmosphere 2-amino-6-hydroxy-pyridine (19.6 g, 178 mmol) was suspended in acetic acid (100%, 390 mL). Br2 (9.2 mL, 178 mmol) was added at 20° C. over 5 min. The green suspension was stirred at RT for 20 min. The mixture was poured onto H2O (400 mL) and filtered. The filtrate was mixed with brine (200 mL) and extracted with EtOAc (10×400 mL). The combined organic phases were dried (Na2SO4), filtered and concentrated to afford 6-Amino-5-bromo-pyridin-2-ol as a yellow solid (23 g).

1. additionThe mixture was poured onto H2O (400 mL)
2. filtrationfiltered
3. additionThe filtrate was mixed with brine (200 mL)
4. extractionextracted with EtOAc (10×400 mL)
5. dry with materialThe combined organic phases were dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated