Lithium Hydroxide → HCID 58074618, compound

Participants

Reaction Steps

1-(8-Bromo-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-cyclopropanecarboxylic acid ethyl ester (0.22 g, 0.64 mmol) was dissolved in 1,4-dioxan (15 mL). LiOH (0.085 g, 1.9 mmol) in H2O (3 mL) was added. The mixture was stirred at RT overnight. The solvent was evaporated. H2O (50 mL) was added and the aqueous phase was adjusted to pH 1 with 2 N HCl. The aqueous phase was extracted (×3) with EtOH/DCM 1/10. The combined organic phases were washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the title compound as a solid.

Provenance & Evidence