HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1848429Generated: October 31, 2026
Ethyl Acetate → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate
https://huagongshe.com/reaction/1848429
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 1-N-Boc-4-Piperidinecarboxylic acid methyl ester | HCID 392870 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 2764081 | — |
Reaction Steps
A mixture of 70 g of LiAlH4 in 1500 mL of THF was cooled to 0° C., then 180 g of 1-tert-butyl 4-methyl piperidine-1,4-dicarboxylate in THF was added dropwise. When the reaction was finished, 200 mL of ethyl acetate and solid anhydrous Na2SO4. Water was added until the solution became clear. The mixture was filtered and the filtrate was evaporated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08952166B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-ee3d6c3bb13548f68e9260a95215b193 |
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| Source note | uspto-grants-2015_02 |
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