HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate → 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate | HCID 10015184 | — |
| Reactant | 4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate | HCID 10890188 | — |
| Reactant | HCID 86709456 | HCID 86709456 | — |
| Product | 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one | HCID 86709454 | — |
Reaction Steps
The title compound was prepared from 3-oxo-2,8-diaza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester and 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate in two steps in an analogous fashion to that described for 2-(4-Methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,9-diazaspiro[5.5]undecan-1-one (I-19) above.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952166B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-e674811338d84ee9a19ee55daa1cf20e |
| Source note | uspto-grants-2015_02 |