反应详情

To a solution of ethyl 2-methyl-3-oxopentanoate (5.0 g, 34.7 mmol) in chloroform at 0° C. was added bromine (1.79 mL, 34.7 mmol) in chloroform (10 mL) drop-wise. The resulting solution was stirred at rt for 16 h. The solution was washed with water, dried over sodium sulfate, and concentrated to give the title compound. 1HNMR (500 MHz, CDCl3), δ4.781-4.740 (dd, J=6.6 Hz, 1H), 4.140-4.098 (dd, J=7.0 Hz, 1H), 3.770 (s, 3H), 1.797-1.783 (d, J=6.6 Hz, 3H), 1.455-1.442 (d, J=7.0 Hz, 3H).

1. washThe solution was washed with water
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated