4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate → 3-Methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4,5]decan-1-one
Reaction equation
[CH3:1][CH:2]1[CH2:6][C:5]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[C:4](=[O:12])[N:3]1[C:13]1[CH2:14][O:15][C:16](=[O:18])[CH:17]=1.F[C:20](F)(F)S(OC1COC(=O)C=1C)(=O)=O>>[CH3:1][CH:2]1[CH2:6][C:5]2([CH2:7][CH2:8][NH:9][CH2:10][CH2:11]2)[C:4](=[O:12])[N:3]1[C:13]1[CH2:14][O:15][C:16](=[O:18])[C:17]=1[CH3:20]Participants
3
Procedure
The title compound was prepared in two steps in an analogous fashion to that described for 3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one (I-22), except starting from 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate (I-9). LC-MS (IE, m/z): 265 (M+1)+.
Sources & evidence
- ORD record
- ord-46667e72d2e04a93b46a77213170211d
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952166B2
Reaction notes
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