3-Methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one → 2-(4-(Methoxymethyl)-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:8](=[O:9])[O:7][CH2:6][C:5]=1[N:10]1[CH2:14][CH2:13][C:12]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[C:11]1=[O:27].CC1CC2(CCNCC2)C(=O)N1C1COC(=O)C=1>>[CH3:1][O:2][CH2:3][C:4]1[C:8](=[O:9])[O:7][CH2:6][C:5]=1[N:10]1[CH2:14][CH2:13][C:12]2([CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[C:11]1=[O:27]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from tert-butyl 2-(4-(methoxymethyl)-5-oxo-2,5-dihydrofuran-3-yl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate in an analogous fashion as described for 3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one (I-22, last step).
Sources & evidence
- ORD record
- ord-ca12263b9b7c4202a79b4e2af1956fcb
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952166B2
Reaction notes
Loading…