HCID 66643955, compound → HCID 66643986, compound

HRID 1848510Notes

Reaction equation

HRID 1848510 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH:12]=[CH2:13]>CO.[Pd]>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH2:12][CH3:13]

Participants

4

Reactant 1

HCID 66643955HCID 66643955, compound

Product 1

HCID 66643986HCID 66643986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-4-vinyl-2-benzofuran-1(3H)-one (2.0 g, 8.37 mmol) and Pd/C (400 mg) in 50 mL of MeOH was stirred at rt. under H2 (1 atm) overnight, and then filtered. The filtrate was concentrated. The resulting oil was purified by column chromatography to give 5-bromo-4-ethyl-2-benzofuran-1(3H)-one.

Workup

  1. filtrationunder H2 (1 atm) overnight, and then filtered
  2. concentrationThe filtrate was concentrated
  3. customThe resulting oil was purified by column chromatography

Sources & evidence

ORD record
ord-8889c31dcd414b00a174bc6d9baf280b
Source dataset
uspto-grants-2015_02
Patent number
US08952166B2

Reaction notes

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