反应详情

Into a 10000-mL 4-necked round-bottom flask was placed a solution of ethyl 1-benzyl-4-(cyanomethyl)-3-oxopiperidine-4-carboxylate (180 g, 599.30 mmol) in acetic acid/methanol (1:1, 5.4 L) and platinum oxide (27 g, 118.90 mmol). The flask was then flushed and charged with hydrogen and stirred overnight at room temperature. After filtration under nitrogen through CELITE®, the filtrate was concentrated under vacuum to give the title compound.

1. customInto a 10000-mL 4-necked round-bottom flask was placed
2. customThe flask was then flushed
3. additioncharged with hydrogen
4. filtrationAfter filtration under nitrogen through CELITE®
5. concentrationthe filtrate was concentrated under vacuum