Tetrabutylammonium Fluoride → 8-(1-Hydroxy-1-(1-hydroxy-4-methyl-1,3-dihydroisobenzofuran-5-yl)-2-methylpropan-2-yl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of Step I (1.282 g, 2.192 mmol) in tetrahydrofuran (50 ml) was added TBAF (2.63 mL, 2.63 mmol) at 0° C., and the resulting solution was stirred at 0° C. for 2 h. After concentration, the residue was purified on TLC eluting with 10% MeOH/DCM to give the title compound. LC/MS: (M+1)+: 471.20.

Provenance & Evidence