反应详情

温度

0 °C

To a solution of the product of Step J (340 mg, 0.723 mmol) in methylene chloride (30 mL) was added PCC (311 mg, 1.45 mmol) at 0° C. and the resulting solution was stirred at 0° C. for 2 h. The reaction mixture was partitioned between methylene chloride and saturated bicarbonate, and the alkaline phase was extracted with methylene chloride (3×50 mL). The combined organic phase was dried over sodium sulfate, concentrated and the residue was purified on TLC using 10% methanol/methylene chloride as developing solvents to give the title compound. LC/MS: (M+1)+: 469.20.

1. customThe reaction mixture was partitioned between methylene chloride and saturated bicarbonate
2. extractionthe alkaline phase was extracted with methylene chloride (3×50 mL)
3. dry with materialThe combined organic phase was dried over sodium sulfate
4. concentrationconcentrated
5. customthe residue was purified on TLC