HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Bromo-4-chlorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Bromo-4-chlorobenzoic acid | HCID 2735544 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Bromo-4-chlorobenzoyl chloride | HCID 20229730 | — |
Reaction Steps
To 3-bromo-4-chloro-benzoic acid (9.4 g, 40 mmol) in dry DCM (100 mL), was added DMF (0.5 mL) followed by addition of oxalyl chloride (22.5 mL, 55 mmol, 2M in DCM) slowly. The mixture was stirred for 1 hr, then concentrated to yield 3-bromo-4-chloro-benzoyl chloride as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952161B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-81df8ea0845140d1bc75193118dc866d |
| Source note | uspto-grants-2015_02 |