Thionyl Chloride → 2-(4-Chlorophenyl)ethyl chloride

Participants

Reaction Conditions

Reaction Steps

Into a 250-mL round-bottom flask equipped with magnetic stirring, a thermocouple, a condenser, and a nitrogen bubbler vented to a caustic scrubber, was charged 2-(4-chlorophenyl)ethanol (25.026 g, 160 mmol) N,N-dimethylformamide (0.621 mL, 7.99 mmol) was added and the mixture was heated to 58° C. Thionyl Chloride (12.25 mL, 168 mmol) was charged over 1 h while the temperature was maintained at <65° C. Upon completion of the addition, the mixture was stirred at 60 to 64° C. for 2.5 h, and then allowed to gradually cool to room temperature and stirred overnight to give a clear, golden oil.

Provenance & Evidence