Thionyl Chloride → HCID 90410273, compound

HRID 1848707Notes

Reaction equation

HRID 1848707 reaction equation
[F:1][C:2]1[C:3]([CH2:8]O)=[N:4][N:5]([CH3:7])[CH:6]=1.S(Cl)([Cl:12])=O>C(Cl)Cl>[Cl:12][CH2:8][C:3]1[C:2]([F:1])=[CH:6][N:5]([CH3:7])[N:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 904101411628350-49-1

Product 1

HCID 90410273HCID 90410273, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 25 mL round-bottomed flask containing (4-fluoro-1-methyl-1H-pyrazol-3-yl)methanol (285 g, 2.2 mmol) in dry DCM (10 mL), was added thionyl chloride (0.3 mL, 4.4 mmol). The reaction mixture was stirred at RT for 2 h then concentrated to dryness to provide the title compound, which was carried forward without further purification.

Workup

  1. concentrationthen concentrated to dryness

Sources & evidence

ORD record
ord-792a802e233847b6893a6c528f3bd105
Source dataset
uspto-grants-2015_02
Patent number
US08952177B2

Reaction notes

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