HCID 86706788, compound → HCID 86706787, compound

HRID 1848771Notes

Reaction equation

HRID 1848771 reaction equation
[NH2:1][C@@H:2]([CH3:17])[C:3]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4].[OH:18][C:19]1[CH:31]=[CH:30][C:22]2[C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:24][O:25][C:21]=2[CH:20]=1>CO>[NH2:1][C@@H:2]([CH3:17])[C:3]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4].[OH:18][C:19]1[CH:31]=[CH:30][C:22]2[C@H:23]([CH2:26][C:27]([OH:29])=[O:28])[CH2:24][O:25][C:21]=2[CH:20]=1

Participants

3

Reactant 1

HCID 86706788HCID 86706788, compound

Product 1

HCID 86706787HCID 86706787, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

A solution of (6-hydroxy-1-benzofuran-3-yl)acetic acid (S)-2-amino-1,1-diphenylpropan-1-ol salt (19.64 g) and dichloro[(+)-1,2-bis((2R,5R)-2,5-diisopropylphosphorano)benzene]ruthenium (II)-N,N-dimethylformamide complex (2.3 mg) in dehydrated methanol (90 ml) was stirred at 35° C. for 22 hr under a hydrogen atmosphere (1.1 MPa). To the reaction solution was added methanol (9 mL) to give a methanol solution of the title compound. 81.3% de

Sources & evidence

ORD record
ord-a8b145a37ea34d45aeb03d80549ba4fd
Source dataset
uspto-grants-2015_02
Patent number
US08952185B2

Reaction notes

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