2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid → HCID 60164157, compound

Participants

Reaction Steps

(6-Hydroxy-1-benzofuran-3-yl)acetic acid (0.050 g, 0.26 mmol) and dichloro[(+)-1,2-bis((2R,5R)-2,5-diisopropylphosphorano)benzene]ruthenium (II)-N,N-dimethylformamide complex (1.9 mg, 0.0026 mmol) and sodium methoxide (14.0 mg, 0.26 mmol) were charged, and purged with argon. Methanol (1 mL) was added thereto, and the mixture was stirred at room temperature for 12 hr under a hydrogen atmosphere (1.0 MPa). The obtained reaction mixture was analyzed by liquid chromatography to give the title compound (conversion ratio 99.9%, optical purity 84.1% ee(S)).

Provenance & Evidence