Dimethylformamide → 2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

2-Bromo-1,3-dimethyl-5-[3-(methylsulfonyl)propoxy]benzene (0.10 g), 3-formylphenylboronic acid (0.05 g, 1.05 eq), potassium phosphate (0.13 g, 2.0 eq) and 1,1′-bis(diphenylphosphino)ferrocene-palladium (II) dichloride-dichloromethane complex (PdCl2(dppf)) (5 mg, 2 mol %) were charged in a glass tube, and N,N-dimethylformamide (1 mL) and water (0.5 mL) were added thereto. After argon substitution, the mixture was stirred at 60° C. for 3 hr. The obtained reaction mixture was analyzed by high performance liquid chromatography to find the title compound (81.8% peak area).

Provenance & Evidence