Lithium Chloride → 2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

2-Bromo-1,3-dimethyl-5-[3-(methylsulfonyl)propoxy]benzene (0.10 g), 3-formylphenylboronic acid (0.05 g, 1.05 eq), lithium chloride (0.026 g, 2.0 eq), palladium acetate (1.4 mg, 2 mol %) and tri-tert-butylphosphonium tetrafluoroborate (1.8 mg, 2 mol %) were charged in a glass tube, and tetrahydrofuran (1 mL) and water (0.5 mL) were added thereto. After argon substitution, the mixture was stirred at 60° C. for 3 hr. The obtained reaction mixture was analyzed by high performance liquid chromatography to find the title compound (82.9% peak area).

Provenance & Evidence