Boron tribromide → HCID 178434282, compound

HRID 1848821Notes

Reaction equation

HRID 1848821 reaction equation
B(Br)(Br)Br.C[O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[C:9]([CH3:16])=[N:10][NH:11]2>ClCCl>[CH3:16][C:9]1[C:8]2[C:7]([OH:6])=[CH:15][CH:14]=[CH:13][C:12]=2[NH:11][N:10]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 178489088HCID 178489088, compound

Product 1

HCID 178434282HCID 178434282, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 1M solution of BBr3 (6.57 mL) was added to a solution of EXAMPLE 44A (0.71 g) in dichloromethane (30 mL), and the reaction was stirred for 18 hours. The reaction was quenched by the slow addition of methanol, and the mixture was concentrated and chromatographed on silica gel using 10% methanol/ethyl acetate.

Workup

  1. customThe reaction was quenched by the slow addition of methanol
  2. concentrationthe mixture was concentrated
  3. customchromatographed on silica gel using 10% methanol/ethyl acetate

Sources & evidence

ORD record
ord-1493598927a846b39e8cdfd32b157a72
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

Loading…