Water → 3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	4-Chloro-3-nitrobenzenesulfonamide	HCID 7324	—
Reactant	Triethylamine	HCID 8471	—
Reactant	1-(Oxan-4-yl)piperidin-4-amine dihydrochloride	HCID 45156751	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide	HCID 67126384	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

A mixture of EXAMPLE 49B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 49B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide (20.3 g), heated at 90° C. for 16 hours, cooled and concentrated. 10% Methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and then the mixture was filtered.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08952157B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-3161eb70e51841ae840f795d169c5ac4
Source note	uspto-grants-2015_02