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Sodium Carbonate → 6-(4-Chlorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-Chlorophenylboronic acid | HCID 74299 | — |
| 反応物 | 1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- | HCID 95062 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6-(4-Chlorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde | HCID 86642873 | — |
反応手順
To a solution of 6-bromobenzo[d][1,3]dioxole-5-carbaldehyde (4.6 g), 4-chlorophenylboronic acid (3.78 g) and tetrakis(triphenylphosphine)palladium(0) (0.232 g) in toluene (80 mL) and methanol (30 mL) was added 2N aqueous Na2CO3 (30 mL). The mixture was stirred at reflux overnight. The mixture was diluted with ether (400 mL) and washed with water, brine and dried over Na2SO4. After filtration and concentration of the solvent, the residue was loaded on a column and eluted with 3% ethyl acetate in hexane to give the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08952157B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-85731bc641d34a45af899bf551e0b710 |
| 出典メモ | uspto-grants-2015_02 |