Potassium Phosphate, Tribasic → Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	4-Amino-2-chlorophenol	HCID 77578	—
Reactant	Benzoic acid, 2,4-difluoro-, ethyl ester	HCID 2737170	—
Solvent	Diglyme	HCID 8150	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate	HCID 67228057	—

Reaction Conditions

Temperature	110 °C

Reaction Steps

To a solution of ethyl 2,4-difluorobenzoate (6.48 g) and 4-amino-2-chlorophenol (5.0 g) in diglyme (40 mL) was added K3PO4 (7.39 g). The mixture was stirred at 110° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08952157B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-df93be8cc7f042b6a10697d419f36097
Source note	uspto-grants-2015_02