HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → Ethyl 2-(4-amino-2-chloro-5-ethynylphenoxy)-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Ethyl 2-(4-amino-2-chloro-5-((trimethylsilyl)ethynyl)phenoxy)-4-fluorobenzoate | HCID 67226491 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 2-(4-amino-2-chloro-5-ethynylphenoxy)-4-fluorobenzoate | HCID 87316240 | — |
Reaction Steps
To a solution of EXAMPLE 242C (2.69 g) in methanol (20 mL) was added CsF (5 g). The mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was dissolved in ethyl acetate (200 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952157B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-f6b0cbd5cba84ac29a09928d665d97bb |
| Source note | uspto-grants-2015_02 |