HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178453983, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | tert-butyl N-(4-oxocyclohexyl)carbamate | HCID 1512535 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2) | HCID 44120481 | — |
| Solvent | Titanium isopropoxide | HCID 11026 | — |
| Product | HCID 178453983 | HCID 178453983 | — |
Reaction Steps
To a solution of EXAMPLE 336B (1 g) and tert-butyl 4-oxocyclohexylcarbamate (0.877 g) stirred for 24 hours at room temperature in titanium(IV) isopropoxide (2.410 mL), methanol (2 mL) was added followed by careful addition of sodium borohydride (0.311 g). The reaction mixture was quenched with water, extracted with ether, dried and concentrated. The crude product was purified by flash chromotography (silica 80 g, 50%-100% acetone/hexanes) providing the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952157B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-9132d43f0e78493fa0b460b1d569b526 |
| Source note | uspto-grants-2015_02 |