HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester | HCID 67226997 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester | HCID 67227925 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952157B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-50f992168f3144e3926f8921efb71ecd |
| Source note | uspto-grants-2015_02 |