HCID 67227429, compound → HCID 67226815, compound

HRID 1848933Notes

Reaction equation

HRID 1848933 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([N:19]3[CH2:24][CH2:23][N:22]([CH2:25][C:26]4[CH2:27][C:28]5([CH2:44][CH2:45][C:46]=4[C:47]4[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=4)[CH2:33][CH2:32][N:31](C(OCC4C=CC=CC=4)=O)[CH2:30][CH2:29]5)[CH2:21][CH2:20]3)[CH:12]=[CH:13][C:14]=2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][C:3]=1[Cl:54]>C(O)C.[Pd]>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([N:19]3[CH2:20][CH2:21][N:22]([CH2:25][C:26]4[CH2:27][C:28]5([CH2:44][CH2:45][C:46]=4[C:47]4[CH:48]=[CH:49][C:50]([Cl:53])=[CH:51][CH:52]=4)[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]5)[CH2:23][CH2:24]3)[CH:12]=[CH:13][C:14]=2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][C:3]=1[Cl:54]

Participants

4

Reactant 1

HCID 67227429HCID 67227429, compound

Product 1

HCID 67226815HCID 67226815, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of EXAMPLE 391G (1.02 g) in ethanol (20 mL) was added Pd/C (10%, 150 mg). The mixture was stirred for 5 hours. The mixture was filtered and the filtrate was concentrated to provide the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-51a96f34b2ff4d92b6f0c451fd800d1d
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

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