HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(2S)-pyrrolidine-2-carbonitrile → (S)-1-[8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carbonyl]-pyrrolidine-2-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (2S)-pyrrolidine-2-carbonitrile | HCID 5706552 | — |
| Edukt | 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid | HCID 58203883 | — |
| Produkt | (S)-1-[8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carbonyl]-pyrrolidine-2-carbonitrile | HCID 58204009 | — |
Reaktionsschritte
Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (S)-pyrrolidine-2-carbonitrile (1.2 equiv) to give 137 (14.2 mg, M+1 392.1)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08952043B2 |
| Quelldatensatz | uspto-grants-2015_02 |
| ORD ID | ord-bf8d01c09ca041b2aad019fc0fb2cce0 |
| Quellennotiz | uspto-grants-2015_02 |